Details
Manufacturer supply top purity P-BROMOPHENYL HYDRAZINE 589-21-9 with ISO standards
- Molecular Formula: C6H7BrN2
- Molecular Weight: 187.039
- Vapor Pressure: 0.00278mmHg at 25°C
- Melting Point: 102-104 °C
- Refractive Index: 1.68
- Boiling Point: 285.6 °C at 760 mmHg
- PKA: 4.93±0.20(Predicted)
- Flash Point: 126.5 °C
- PSA： 38.05000
- Density: 1.666 g/cm3
- LogP: 2.50800
P-BROMOPHENYL HYDRAZINE(Cas 589-21-9) Usage
|
Purification Methods |
Crystallise the hydrazine from H2O. The hydrochloride crystallises from EtOH/H2O with m 213-214o, and the tosylate has m 212o (from EtOH). [Beilstein 15 H 434, 15 I 117, 15 II 160, 15 III 289, 15 IV 282.] |
|
General Description |
P-Bromophenyl hydrazine is a key intermediate used in the synthesis of eletriptan via Fischer indole cyclization. Its preparation involves the reduction of p-bromophenyldiazonium salts, optimized using L-ascorbic acid to enhance efficiency and sustainability. P-BROMOPHENYL HYDRAZINE serves as a crucial building block in the streamlined, cost-effective, and environmentally friendly production of eletriptan, demonstrating its importance in pharmaceutical synthesis. |
InChI:InChI=1/C6H7BrN2/c7-5-1-3-6(9-8)4-2-5/h1-4,9H,8H2
589-21-9 Relevant articles
NOVEL COMPOUNDS AS NADPH OXIDASE INHIBITORS
-
Paragraph 0291; 0292, (2020/04/09)
The present invention is related to new ...
Lewis Acid Catalyzed Annulation of Cyclopropane Carbaldehydes and Aryl Hydrazines: Construction of Tetrahydropyridazines and Application Toward a One-Pot Synthesis of Hexahydropyrrolo[1,2- b]pyridazines
Dey, Raghunath,Kumar, Pankaj,Banerjee, Prabal
, p. 5438 - 5449 (2018/05/28)
In this report, a facile synthesis of te...
5-Bromo-1-(4-chlorobenzyl)-1h-indole-2-carboxamides as new potent antibacterial agents
Mane, Yogesh D.,Patil, Smita S.,Biradar, Dhanraj O.,Khade, Bhimrao C.
, p. 327 - 332 (2018/11/27)
Ten 5-bromoindole-2-carboxamides were sy...
Design, synthesis, and antimicrobial activity of novel 5-substituted indole-2-carboxamide derivatives
Mane, Yogesh D.,Sarnikar, Yuvaraj P.,Surwase, Santosh M.,Biradar, Dhanraj O.,Gorepatil, Pratapsinha B.,Shinde, Vishnu S.,Khade, Bhimrao C.
, p. 1253 - 1275 (2017/02/10)
Abstract: A series of novel, bioactive 5...
589-21-9 Process route
-
-
622-88-8,41931-18-4
4-bromophenylhydrazine hydrochloride
-
-
589-21-9
(4-bromophenyl)hydrazine
| Conditions | Yield |
|---|---|
|
With
sodium carbonate;
In
dichloromethane; water;
|
|
|
With
sodium hydroxide;
In
tetrahydrofuran; diethyl ether; water;
at 0 - 20 ℃;
for 1h;
|
|
|
With
sodium hydroxide;
In
tetrahydrofuran; water;
for 0.5h;
|
4.45 g
|
|
With
ammonium hydroxide;
at 0 ℃;
|
|
|
With
potassium carbonate;
In
water;
at 20 ℃;
for 0.25h;
|
|
|
With
potassium carbonate;
In
water;
at 20 ℃;
for 0.25h;
Inert atmosphere;
|
-
-
412328-47-3
N-(4-bromophenyl)-nitramine
-
-
589-21-9
(4-bromophenyl)hydrazine
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride; tin(ll) chloride;
In
water;
for 4h;
Cooling with ice;
|
85%
|
589-21-9 Upstream products
-
1077-20-9
acetone p-bromophenylhydrazone
-
103-02-6
acetone phenylhydrazone
-
2028-85-5
(4-bromophenyl)diazonium chloride
-
100-63-0
phenylhydrazine
589-21-9 Downstream products
-
69211-14-9
1,5-bis-(4-bromo-phenyl)-formazan
-
6949-82-2
(Z)-4-[2-(4-bromophenyl)hydrazino]-4-oxobut-2-enoic acid
-
91182-63-7
5-nitro-thiophene-2-carbaldehyde-(4-bromo-phenylhydrazone)
-
91182-62-6
4-nitro-thiophene-2-carbaldehyde-(4-bromo-phenylhydrazone)